Laparoscopy for relapsing paralytic ileus in multiple sclerosis: a video case report
Modified manuscript (added reference to video, 4. October 2019)
a Neurocentre of Southern Switzerland, Civic Hospital of Lugano, Switzerland
b Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy
c Department of Surgery, Civic Hospital of Lugano, Lugano, Switzerland
d Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
Autonomic failure, especially of the gastrointestinal tract, has been detected in a wide range of multiple sclerosis patients with very variable frequencies. Acute manifestations of gastrointestinal dysfunction, however, are rarely reported. We describe an multiple sclerosis patient with a relapsing form of acute paralytic ileus in the context of acute autonomic failure requiring surgery.
Keywords: multiple sclerosis, autonomic failure, dysautonomia, autonomic nervous system, paralytic ileus, sub-obstructive ileus, enteric nervous system
Autonomic failure (AF) has been previously described in patients with multiple sclerosis (MS) . Prominent involvement of the cardiovascular, urinary and gastrointestinal branches of the autonomic nervous system (ANS) has been detected in a wide range of MS patients with very variable frequencies , either through dedicated questionnaires, or by means of laboratory autonomic function tests (AFT) .
Gastrointestinal dysfunction is particularly remarkable in MS, with both constipation and faecal incontinence being its most prevalent manifestations [4, 5]. In one questionnaire-based series of 218 patients with MS, 43% claimed to be constipated, 51% complained of faecal incontinence and 68% of any bowel dysfunction . Patients with higher disability and longer duration of MS tend to have greater prevalence and severity of bowel symptoms .
Acute manifestations of gastrointestinal dysfunction, ranging from acute dysphagia to gastroparesis to acute paralytic ileus are, however, rarely reported (for references, see table 1). In this case report, we describe a patient with a stable MS presenting with a relapsing form of acute paralytic ileus requiring surgery.
Report of case
A 44-year-old woman with a 10-year history of clinically stable, relapsing-remitting MS characterised by mild functional disability (Expanded Disability Status Scale, EDSS 2.0 defined by relevant fatigue) and treated with interferon beta-1a 44 µg (Rebif®) for the last 5 years was admitted to the emergency department because of sudden abdominal pain, nausea and vomiting. She had last passed stools 2 days before and had no fever. Her medical history was otherwise unremarkable, she had no allergy history, her food habits had been stable and she had not travelled during the previous months. Clinical examination was remarkable for epigastric tenderness, with no signs of peritoneal irritation. Routine laboratory tests, including inflammatory indices, liver and biliary tract, kidney function, lactates and creatine phosphokinase were all normal. A detailed review of ANS symptoms by use of the Italian version of the Composite Autonomic Symptoms Scale-31 (COMPASS-31)  disclosed a selective involvement of the enteric nervous system in terms of constipation. Orthostatic intolerance, pupillomotor, vasomotor, secretomotor or bladder dysfunctions were absent. A simple supine versus standing blood pressure measurement excluded orthostatic hypotension or postural tachycardia. A thorough neurological examination did not show any other sign of AF.
Abdominal computed tomography (CT) showed signs of mechanical small bowel obstruction with a possible beak and faeces sign. As there were no clear signs of bowel wall injury or free fluid collection, conservative treatment was tried and interrupted after 24 hours, as the patient had faecal vomiting. An emergency diagnostic laparoscopy excluded mechanical obstruction, but showed an atonic bowel with complete absence of peristalsis (video 1). Liver and omental biopsies, as well as a cytological sample of intra-abdominal fluid, were collected and yielded negative results, thus excluding infectious, metabolic, ischaemic or pharmacological causes for the ileus. The clinical course was free from complications and the patient was discharged home 4 days later; no treatment was started.
After 5 days, she consulted our emergency department for recurrence of abdominal pain, nausea and vomiting, which had started 24 hours earlier. She had no fever, nor diarrhoea. Peristalsis was absent and no clinical signs of peritoneal irritation were found. Laboratory tests, abdominal radiography and CT scan were repeated, confirming the same diagnosis of paralytic ileus without mechanical obstruction, which resolved after treatment with amidotrizoid acid and neostigmine.
Spinal 3T-magnetic resonance imaging (MRI) disclosed a stable lesion load compared to the year before, with a non-enhancing lesion anteriorly in the lower medulla, as well as multiple non-enhancing cervical and dorsal demyelinating lesions (at C1-2-3-4 and T8-9 levels) (fig. 1). Imaging of the lumbosacral spine did not show any pathological finding. The patient was discharged 4 days later. At a 1-year follow-up, the patient is stable and still taking interferon beta-1a. No new relapses took place.
This case adds up to a growing number of reported cases of acute paralytic ileus occurring in MS patients (table 1). Historically, it has always been postulated that AF in MS patients is probably due to plaques distributed throughout the brainstem and spinal cord affecting anatomically widespread autonomic regulatory areas and their connections [1, 11, 15]. According to this viewpoint, it is also believed that the level of AF correlates both to spinal involvement and to MS disease severity [16–18]. Our patient presented multiple chronic and newly developed spinal lesions and her medical history was remarkable for dysautonomic symptoms, mostly involving the gastrointestinal system. Given that infectious, compressive or structural causes for the ileus were excluded, we postulated that a relationship between a relapse of MS and the paralytic ileus is the most plausible explanation (table 2 for a selected differential diagnosis of ileus and mechanical obstruction).
|Article||Clinical description||Diagnosis||MRI findings|
|Nomura et al. 2015 ||7-year-old child with acute abdominal pain and paralytic ileus||MS-RR||Lesion on T4-T12|
|Ielpo et al. 2010 ||64-year-oldwoman, intestinal pseudo-obstruction||MS|
|Lane et al. 2005 ||49-year-oldman, intestinal pseudo-obstruction||MS-PP|
|49-year-oldwoman, gastroparesis, oesophageal dysmotility, faecal incontinence, intestinal pseudo-obstruction, megacolon||MS|
|35-year-oldwoman, severe vomiting, intestinal pseudo-obstruction||MS-SP|
|Feldman et al. 1977 ||Paralytic ileus|
|Williams et al. 1972 ||Pseudo-obstruction||Acute myelitis|
|Ito et al. 2004 ||19-year-oldgirl, pseudo-obstruction||MS||Left medullary basis, vagal nerve root|
|Causes of paralytic ileus may include:|
• Bacterial or viral gastroenteritis
• Chemical, electrolyte, or mineral imbalances
• Abdominal surgery
• Decreased blood supply to the intestines
• Abdominal infections (e.g. appendicitis)
• Kidney or lung disease
• Drugs, especially narcotics
|Mechanical causes of bowel obstruction may include:|
• Adhesions or scar tissue that form after surgery
• Foreign bodies
• Gallstones (rare)
• Impacted stool
• Tumours blocking the intestines
Interestingly, it has been recently proposed that demyelination in MS does not occur only within the central but also in the peripheral nervous system. Early neuropathological reports described segmental demyelination, hypertrophic neuropathy and a reduction in myelin thickness in a few MS patients [19, 20]. A proof-of-concept study visualised and quantified peripheral nerve lesions in MS in vivo by means of high-resolution MRI studies . These more recent findings offer grounds for speculation; indeed, in contrast to some of the previous records , in our case, none of the new spinal lesions showed contrast enhancement on MRI. It could be argued that more peripheral lesions, invisible to routine neuroimaging, might have played a role in precipitating the two episodes of paralytic ileus by unbalancing a pre-existing precarious equilibrium within the increased spinal lesion load.
Once all other causes of paralytic ileus have been ruled out or treated , neurologists should keep in mind that MS may cause acute and severe impairment of any part of the ANS, particularly in those patients with a previous history of dysautonomia and even in the absence of new contrast-enhanced spinal lesions.
Video on https://sanp.ch/en/online-only-content/post/laparoscopy-for-relapsing-paralytic-ileus-in-multiple-sclerosis-a-video-case-report/
Chiara Zecca and Claudio Gobbi contributed equally to this work.
Funding / potential competing interests
No financial support and no other potential conflict of interest relevant to this article was reported.
Dr Claudio Gobbi, MD, Neurocentre of Southern Switzerland, Via Tesserete, 48, CH-6900 Lugano, claudio.gobbi[at]eoc.ch
1 McDougall AJ, McLeod JG. Autonomic nervous system function in multiple sclerosis. J Neurol Sci. 2003;215(1-2):79–85 . http://dx.doi.org/10.1016/S0022-510X(03)00205-3 PubMed
2 Haensch CA, Jörg J. Autonomic dysfunction in multiple sclerosis. J Neurol. 2006;253(S1, Suppl 1):I3–9 . http://dx.doi.org/10.1007/s00415-006-1102-2 PubMed
3 Racosta JM, Sposato LA, Morrow SA, Cipriano L, Kimpinski K, Kremenchutzky M. Cardiovascular autonomic dysfunction in multiple sclerosis: a meta-analysis. Mult Scler Relat Disord. 2015;4(2):104–11 . http://dx.doi.org/10.1016/j.msard.2015.02.002 PubMed
4 Levinthal DJ, Rahman A, Nusrat S, O’Leary M, Heyman R, Bielefeldt K. Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis. Mult Scler Int. 2013;2013:319201 . http://dx.doi.org/10.1155/2013/319201 PubMed
5 Wiesel PH, Norton C, Glickman S, Kamm MA. Pathophysiology and management of bowel dysfunction in multiple sclerosis. Eur J Gastroenterol Hepatol. 2001;13(4):441–8 . http://dx.doi.org/10.1097/00042737-200104000-00025 PubMed
6 Hinds JP, Eidelman BH, Wald A. Prevalence of bowel dysfunction in multiple sclerosis. A population survey. Gastroenterology. 1990;98(6):1538–42 . http://dx.doi.org/10.1016/0016-5085(90)91087-M PubMed
7 Nortvedt MW, Riise T, Frugård J, Mohn J, Bakke A, Skår AB, et al.Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis. Mult Scler. 2007;13(1):106–12 . http://dx.doi.org/10.1177/1352458506071210 PubMed
8 Pierangeli G, Turrini A, Giannini G, Del Sorbo F, Calandra-Buonaura G, Guaraldi P, et al.Translation and linguistic validation of the Composite Autonomic Symptom Score COMPASS 31. Neurol Sci. 2015;36(10):1897–902 . http://dx.doi.org/10.1007/s10072-015-2278-y PubMed
9 Nomura S, Shimakawa S, Kashiwagi M, Tanabe T, Fukui M, Tamai H. Acute abdominal pain as the only symptom of a thoracic demyelinating lesion in multiple sclerosis. Brain Dev. 2015;37(10):983–7 . http://dx.doi.org/10.1016/j.braindev.2015.03.006 PubMed
10 Ielpo B, Venditti D, Manfredi P, Balassone V, Petrella G. Intestinal pseudo-obstruction in patient affected by multiple sclerosis: case report. Colorectal Dis. 2010;12(7 Online):e175. PubMed
11 Lane SW, Pender MP. Intestinal pseudo-obstruction complicating multiple sclerosis. Intern Med J. 2005;35(3):191–2 . http://dx.doi.org/10.1111/j.1445-5994.2004.00753.x PubMed
12 Feldman S. [Paralytic ileus complicating multiple sclerosis]. Harefuah. 1977;92(5):203–5. [Article in Hebrew]. PubMed
13 Williams HT, Turner DT. Acute myelitis presenting as spastic colonic ileus. Br J Surg. 1972;59(11):918 . http://dx.doi.org/10.1002/bjs.1800591117 PubMed
14 Ito T, Sakakibara R, Sakakibara Y, Mori M, Hattori T. Medulla and Gut. Intern Med. 2004;43(11);1091
15 Vita G, Fazio MC, Milone S, Blandino A, Salvi L, Messina C. Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions. J Neurol Sci. 1993;120(1):82–6 . http://dx.doi.org/10.1016/0022-510X(93)90029-X PubMed
16 Gunal DI, Afsar N, Tanridag T, Aktan S. Autonomic dysfunction in multiple sclerosis: correlation with disease-related parameters. Eur Neurol. 2002;48(1):1–5 . http://dx.doi.org/10.1159/000064949 PubMed
17 Saari A, Tolonen U, Pääkkö E, Suominen K, Pyhtinen J, Sotaniemi K, et al.Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS. Clin Neurophysiol. 2004;115(6):1473–8 . http://dx.doi.org/10.1016/j.clinph.2004.01.012 PubMed
18 Flachenecker P, Reiners K, Krauser M, Wolf A, Toyka KV. Autonomic dysfunction in multiple sclerosis is related to disease activity and progression of disability. Mult Scler. 2001;7(5):327–34 . http://dx.doi.org/10.1177/135245850100700509 PubMed
19 Hasson J, Terry RD, Zimmerman HM. Peripheral neuropathy in multiple sclerosis. Neurology. 1958;8(7):503–10 . http://dx.doi.org/10.1212/WNL.8.7.503 PubMed
20 Pollock M, Calder C, Allpress S. Peripheral nerve abnormality in multiple sclerosis. Ann Neurol. 1977;2(1):41–8 . http://dx.doi.org/10.1002/ana.410020107 PubMed
21 Jende JME, Hauck GH, Diem R, Weiler M, Heiland S, Wildemann B, et al.Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography. Ann Neurol. 2017;82(5):676–85 . http://dx.doi.org/10.1002/ana.25068 PubMed
22 Harrison ME, Anderson MA, Appalaneni V, Banerjee S, Ben-Menachem T, Cash BD, et al.; ASGE Standards of Practice Committee. The role of endoscopy in the management of patients with known and suspected colonic obstruction and pseudo-obstruction. Gastrointest Endosc. 2010;71(4):669–79 . http://dx.doi.org/10.1016/j.gie.2009.11.027 PubMed
Published under the copyright license
“Attribution – Non-Commercial – NoDerivatives 4.0”.
No commercial reuse without permission.